NTP42

SKU: orb1309312

Description

NTP42 is a potent and selective small molecule antagonist of the thromboxane A2 receptor (TP), exhibiting an IC50 of 3.278 nM. It is a valuable research tool for investigating TP receptor signaling in cardiovascular and thrombotic diseases, applicable in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2055599-51-2
• MW: 515.53
• Purity: 99.09% (May vary between batches)
• Formula: C₂₅H₂₃F₂N₃O₅S
• SMILES: CC(C)(C)NC(=O)NS(=O)(=O)c1cc(ccc1Oc1cccc(c1)-c1ccc(OC(F)F)cc1)C#N
• Target: PPAR|||Prostaglandin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.88 mM);DMSO:30 mg/mL (58.19 mM)

Bioactivity

• In Vivo:
  From haemodynamic assessments, NTP42 reduced the MCT-induced PAH, including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP), being at least comparable to the standard-of-care drugs Sildenafil or Selexipag in bringing about these effects. Moreover, NTP42 was superior to Sildenafil and Selexipag in significantly reducing pulmonary vascular remodelling, inflammatory mast cell infiltration and fibrosis in MCT-treated animals.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arterial, hypertension, inhibit, Inhibitor, NTP 42, NTP42, NTP-42, PAH, Prostaglandin Receptor, ProstaglandinReceptor, pulmonary, thromboxane, TXA2R, TXA2

Compound Identifiers

PubChem CID

124147085