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NTP42

SKU: orb1218497

Description

NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) .

Images & Validation

Key Properties

CAS Number2055599-51-2
MW515.53
Purity>98% (HPLC)
FormulaC25H23F2N3O5S
SMILESCC(C)(C)NC(NS(c(cc(cc1)C#N)c1Oc1cc(-c(cc2)ccc2OC(F)F)ccc1)(=O)=O)=O
TargetPPAR
SolubilityDMSO:30mg/mL (58.19 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: Male Wistar-Kyoto rats. Dosage: 0.25 mg/kg BID. Administration: 28-day drug treatment was initiated within 24 h post-MCT (60 mg/kg). Result: Reduced the MCT-induced PAH, including mPAP and RSVP.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • NTP42 [orb1309312]

    99.09% (May vary between batches)

    2055599-51-2

    515.53

    C25H23F2N3O5S

    100 mg, 1 mg, 50 mg, 10 mg, 5 mg, 2 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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200 mg
500 mg
2 mg
$ 150.00
5 mg
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50 mg
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100 mg
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