NSP1 (SARS-CoV-2) antibody

• Catalog Number: orb1463327
• Category: Antibodies
• Description: Host translation inhibitor Nsp1 is part of the multifunctional protein replicase polyprotein 1ab that is involved in the transcription and replication of viral RNA. NSP1 inhibits the host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Therefore, Nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response by suppressing host gene expression.
• Species/Host: Goat
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Virus
• Isotype: IgG
• Immunogen: Affinity purified recombinant fusion protein Nsp1 of SARS-CoV-2 produced in E. coli.
• Concentration: 3 mg/ml
• Dilution range: WB:1:500-1:2,000
• Form/Appearance: Polyclonal antibody supplied as a 100 µl (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
• Conjugation: Unconjugated
• Target: NSP1 (SARS-CoV-2)
• Storage: Store at -20°C for long-term storage. Store at 2-8°C for up to one month.
• Buffer/Preservatives: PBS, 20% glycerol and 0.05% sodium azide
• Alternative names: Host translation inhibitor, Nsp1 SARS Coronavirus-
• Note: For research use only
• Application notes: The antibody solution should be gently mixed before use.
• Expiration Date: 12 months from date of receipt.