NSC 12

SKU: orb2813914

Description

NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG/FGF/FGFR ternary complex.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 102586-30-1
• MW: 484.52
• Purity: 99.51%
• Formula: C₂₄H₃₄F₆O₃
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@H](CC(C(F)(F)F)(C(F)(F)F)O)O)[H])[H]
• Target: FGFR
• Solubility: DMSO:8 mg/mL (16.51 mM);Ethanol:PBS (pH 7.2)(1:2):Insoluble;Ethanol:8 mg/mL (16.51 mM);DMF:8 mg/mL (16.51 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

NSC 12, NSC12, NSC-12

Compound Identifiers

PubChem CID

97290924