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NSC 12

SKU: orb2813914

Description

NSC 12 is an orally bioavailable pan-FGF inhibitor that traps FGF ligands, blocking FGFR1 signaling and disrupting tumor-promoting ternary complex formation without affecting heparin binding. It demonstrates antitumor activity by inhibiting cancer cell proliferation, angiogenesis, and metastasis in both cellular assays and animal models.

Research Area

Cardiovascular Research, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number102586-30-1
MW484.52
Purity99.51% (May vary between batches)
FormulaC24H34F6O3
SMILESC[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@H](CC(C(F)(F)F)(C(F)(F)F)O)O)[H])[H]
TargetFGFR
SolubilityDMSO:8 mg/mL (16.51 mM);Ethanol:PBS (pH 7.2)(1:2):Insoluble;Ethanol:8 mg/mL (16.51 mM);DMF:8 mg/mL (16.51 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NSC 12, NSC12, NSC-12

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Key Properties

No computed properties available.

Protocol Information

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1 mg
$ 90.00
5 mg
$ 150.00
10 mg
$ 220.00