Clopimozide

SKU: orb1702399

Description

Clopimozide (R-29764) is a long-acting, orally active antipsychotic agent that functions as a calcium channel blocker, competitively inhibiting [³H]niludipine binding. It has been utilized in research to investigate L-type calcium channels and dopaminergic pathways in both in vitro binding assays and in vivo models of schizophrenia.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53179-12-7
• MW: 495.99
• Purity: 99.66%
• Formula: C₂₈H₂₈ClF₂N₃O
• SMILES: O=C1N(C=2C(N1)=CC(Cl)=CC2)C3CCN(CCCC(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3
• Target: Calcium Channel
• Solubility: DMSO:4.96 mg/mL (10 mM)

Bioactivity

• Target IC50:
  α1-adrenoceptor:0.25 µM|D2 receptor:0.01 µM|Ca2+ channel:0.017 µM
• In Vivo:
  Clopimozide (5 and 35 mg) in 10 patients' plasma levels were determined with the radio-immunological method. The product exhibited a marked effect on schizophrenic target symptoms (significant at the 0.001 and 0.01 levels), of at least one week's duration, with an absence of sedation and a low degree of extrapyramidal side effects. Clopimozide appears to be particularly suitable for the neuroleptic long-term treatment of compensated schizophrenic patients with insight into their disease.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Clopimozide, CalciumChannel, Calcium Channel, NSC 335305, NSC335305, NSC-335305, R-29764, R29764, R 29764

Compound Identifiers

PubChem CID

65449