Nrf2 degrader 1

SKU: orb2565648

Description

Nrf2 degrader 1 (compound 1) is a potent PROTAC molecule that induces Nrf2 degradation, demonstrating anticancer activity with IC50 values of 100 nM in A549 cells and 40 nM in LK-2 cells. It is a valuable research tool for studying Nrf2's role in cancer cell proliferation and chemoresistance in vitro.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3025286-00-1
• MW: 826.92
• Formula: C₄₅H₄₂N₆O₈S
• SMILES: O=C(NC1=NC(C2=CC=C3C(=C2)CCN3C(=O)C=4C=CC=CC4C)=C(S1)C)CC=5C=CC=C(OCCOCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8)C5
• Target: PROTACs,Nrf2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170705287