NBE5

SKU: orb3210691

Description

NBE5 is an orally active hydrophobic tag-targeted degrader (HyTTD) of Keap1. It mimics protein misfolding to recruit the molecular chaperone Hsp90 and facilitates the targeted degradation of Keap1 through both the ubiquitin-proteasome pathway and the autophagy-lysosome pathway. This process releases the inhibition of the transcription factor Nrf2 by Keap1, thereby powerfully activating Nrf2-mediated endogenous antioxidant pathways and upregulating downstream antioxidant proteins such as HO-1 and GCLM. NBE5 effectively alleviates oxidative stress and inflammatory damage, demonstrating excellent in vivo activity in a DSS-induced acute colitis mouse model.

Key Properties

• Target: Nrf2,PROTACs,HSP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Nrf2,PROTACs,HSP