NRC-2694

SKU: orb1940704

Description

NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.(In Vitro):NRC-2694 (80 ng) induce comparable inhibition of EGFR expression.(In Vivo):NRC-2694 (10 mg/kg) regresses the tumor in mice. The maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (p.o.), in toxicity studies .

Key Properties

• CAS Number: 936446-61-6
• MW: 418.497
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₆N₄O₃
• SMILES: COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCN1CCOCC1
• Target: EGFR
• Solubility: In Vitro: DMSO : 250 mg/mL (597.39 mM)

Bioactivity

• In Vivo:
  In toxicity studies, the maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (po). NRC-2694 (10 mg/kg) regresses the tumor in mice.
• In Vitro:
  NRC-2694 at 80 ng (190 nm) concentrations causes comparable inhibition of EGFR expression.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR