NRC-2694

SKU: orb1307951

Description

NRC-2694 is a small molecule EGFR antagonist that inhibits cellular proliferation, demonstrating anti-cancer activity. It is utilized in cancer research for both in vitro cell-based assays and in vivo studies to investigate EGFR-driven tumor growth and therapeutic targeting.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 936446-61-6
• MW: 418.49
• Purity: 99.90% (May vary between batches)
• Formula: C₂₄H₂₆N₄O₃
• SMILES: COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCCN1CCOCC1
• Target: EGFR
• Solubility: DMSO:250 mg/mL (597.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.95 mM)

Bioactivity

• In Vivo:
  NRC-2694 (10 mg/kg) regresses the tumor in mice. The maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (p.o.), in toxicity studies .
• In Vitro:
  NRC-2694 (80 ng) induce comparable inhibition of EGFR expression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NRC-2694, NRC2694, NRC 2694, inhibit, EGFR, Epidermal growth factor receptor, ErbB-1, HER1, Inhibitor

Compound Identifiers

PubChem CID

16129168