NP118809

SKU: orb1299910

Description

NP118809

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 41332-24-5
• MW: 460.61
• Purity: 98.68%
• Formula: C₃₂H₃₂N₂O
• SMILES: O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
• Target: Calcium Channel
• Solubility: DMSO:4.61 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  Ca2+ channel, N-type:0.11 μM|Ca2+ channel, L-type:12.2 μM
• In Vitro:
  NP118809 with a total linker length of 3 carbons (n = 1) and which exhibited approximately a 500-fold increased N-type channel blockade compared to compounds in this series with linkers either shorter (n = 0, 2a) or longer (n = 2 4, (2c e). Examination o the effect of NP118809 on functional L-type calcium channel activity showed that this compound was approximately 111-fold more Selective for N-type channel

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

NP 118809, NP118809, NP-118809, inhibit, Inhibitor, 39-1B4, Ca channels, Calcium Channel, Ca2+ channels, CalciumChannel

Compound Identifiers

PubChem CID

4988454