NP118809

SKU: orb1220440

Description

NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).

Key Properties

• CAS Number: 41332-24-5
• MW: 460.61
• Purity: >98% (HPLC)
• Formula: C₃₂H₃₂N₂O
• SMILES: O=C(CC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
• Target: Calcium Channel
• Solubility: DMSO:50 mg/mL (108.55 mM)

Bioactivity

• In Vivo:
  NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
• In Vitro:
  NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

39-1B4

Quick Database Links

Gene Symbol

Calcium Channel