NP-G2-044

SKU: orb1298364

Description

NP-G2-044 is an orally bioavailable small molecule inhibitor of fascin with an IC50 of approximately 2 µM. It has been shown in research to inhibit cancer cell migration and metastasis in experimental models, while also demonstrating potential to modulate antitumor immunity.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1807454-59-6
• MW: 399.37
• Purity: 99.92% (May vary between batches)
• Formula: C₂₁H₁₆F₃N₃O₂
• SMILES: Cc1occc1C(=O)Nc1nn(Cc2ccc(cc2)C(F)(F)F)c2ccccc12
• Target: Wnt/beta-catenin,Others
• Solubility: DMSO:240 mg/mL (600.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  Fascin:2 μM
• In Vivo:
  NP-G2-044 (100 mg/kg; i.p.; daily for 18 days) inhibits breast tumor metastasis in mouse models.
• In Vitro:
  NP-G2-044 inhibits the migration of MDA-MB-231 tumor cells with an IC50 of approximately 10 μM, reducing filopodial and subsequently lamellipodial formation.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

filaments, filopodial, fascin, formation, Inhibitor, metastasis, migration, inhibit, NP G2 044, NPG2044, NP-G-2-044, NP-G2-044, actin, cell

Compound Identifiers

PubChem CID

91844684