NP-G2-044

SKU: orb1218599

Description

NP-G2-044 is an orally active fascin inhibitor, with an IC50 of ~2 μM. It blocks tumor metastasis and increases antitumor immune response.

Key Properties

• CAS Number: 1807454-59-6
• MW: 399.37
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₆F₃N₃O₂
• SMILES: Cc(occ1)c1C(Nc1nn(Cc2ccc(C(F)(F)F)cc2)c2c1cccc2)=O
• Target: fascin
• Solubility: DMSO:100 mg/mL (250.39 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: 6-8 week old female BALB/c mice (mouse model bearing 4T1 tumor cells). Dosage: 100 mg/kg. Administration: i.p.; daily for 18 days. Result: Inhibition of 4T1 mouse mammary tumor cell metastasis to the lung.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

fascin