Nourseothricin sulfate

SKU: orb1309324

Description

Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits prokaryotic protein synthesis and exhibits potent antifungal activity. It is widely used in molecular biology for selection in genetic engineering and in antimicrobial research, both in vitro and in vivo.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 96736-11-7
• MW: 1359.47
• Purity: 99.83% (May vary between batches)
• Formula: C₅₀H₉₄N₂₀O₂₂S
• SMILES: OS(O)(=O)=O.[H][C@]12NC(N[C@@H]3O[C@H](CO)[C@H](OC(N)=O)[C@@H](O)[C@H]3NC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCN)=N[C@]1([H])C(=O)NC[C@H]2O
• Target: Antibiotic|||Antibacterial|||Antifungal
• Solubility: H2O:250 mg/mL (183.9 mM)

Bioactivity

• In Vivo:
  Renal handling of Nourseothricin is characterized in experiments on renal cortical slices under various experimental conditions. Following administration in vivo the renal tubular transport system for organic anions (p-aminohippurate, PAH) is not influenced by Nourseothricin. There is a high degree of accumulation of Nourseothricin in renal cortical slices. In contrast to PAH accumulation there is no influence of nitrogen atmosphere, simultaneous administration of PAH, probenecid or trishydroxyaminomethane on Nourseothricin accumulation. Age dependent differences in Nourseothricin accumulation does not exist.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, Fungal, Nourseothricin, Nourseothricin sulfate, Nourseothricin Sulfate, Inhibitor, inhibit, Streptothricin Sulfate, Streptothricin sulfate, Streptothricin

Compound Identifiers

PubChem CID

155859157