Nortrachelogenin

SKU: orb1682000

Description

Nortrachelogenin ((-)-Wikstromol) is a bioactive lignan isolated from Patrinia scabiosaefolia. It exhibits antifungal properties through membrane disruption and induces apoptosis via a cysteinyl aspartate-specific protease-dependent pathway, making it a compound of interest for microbiological and cancer research.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 34444-37-6
• MW: 374.38
• Purity: 99.63% (May vary between batches)
• Formula: C₂₀H₂₂O₇
• SMILES: COc1cc(C[C@H]2COC(=O)[C@]2(O)Cc2ccc(O)c(OC)c2)ccc1O
• Target: Apoptosis|||Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.67 mM);DMSO:55 mg/mL (146.91 mM)

Bioactivity

• In Vitro:
  Methanolic extract of the root bark of carissa edulis showed anti-plasmodial activity against the chloroquin-senitive (D6) strains of plasmodium falciparum parasite with an IC50 value of 1.95 Dg/ml. From this extract, a lignan compound Nortrachelogenin was isolated and showed anti-plasmodium activity of 14.50 Dg/ml. The structure was determined on the basis of spectroscopic evidence.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, TNF-α, Wikstromol, PGE, HIV, IGF-1R, Fungal, NO, NF-κB, NOS, Nortrachelogenin, IL Receptor, COX, (-)-Nortrachelogenin, (-)-Wikstromol, Akt, Caspase, Apoptosis, Antifection

Compound Identifiers

PubChem CID

394846