NOD1/2 antagonist-1

SKU: orb1744880

Description

This dual NOD1/NOD2 antagonist exhibits IC50 values of 1.13 µM and 0.77 µM, respectively, with a half-life of 67.6 minutes. It is a valuable research tool for studying innate immune signaling and has been shown in research to enhance the antitumor effects of chemotherapeutics like paclitaxel in experimental models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2704623-69-6
• MW: 663.03
• Purity: 99.69% (May vary between batches)
• Formula: C₃₂H₂₈ClF₅N₄O₄
• SMILES: O=C(NCCCOC1=CC=C(C=C1)C(F)(F)F)C2=CC=3N=CN(C(=O)C3C=C2C=4C=CC=C(Cl)C4)CC(=O)N5CCCC(F)(F)C5
• Target: NOD-like Receptor (NLR),NOD
• Solubility: DMSO:25 mg/mL (37.71 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

• Target IC50:
  NOD2:0.77 μM|NOD1:1.13 μM
• In Vivo:
  In the B16 tumor-bearing model, NOD1/2 antagonist-1 (50 mg/kg, intravenous injection, once every other day for 16 days) significantly enhanced the anti-tumor effect of paclitaxel (PTX) .
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• In Vitro:
  NOD1/2 antagonist-1 (0-10 μM, 3 hours) can inhibit C12-iE-DAP-induced or MDP-induced NF-κB activation . NOD1/2 antagonist-1 (0-10 μM, 1 hour) suppresses inflammatory responses by activating NOD1 and NOD2 . NOD1/2 antagonist-1 (0-10 μM, 1 hour) sustainably and dose-dependently reduces the transcriptional levels of IL-6, TNF-α, and IL-8 .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156788057