NL-1

SKU: orb1299051

Description

NL-1

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 188532-26-5
• MW: 335.46
• Purity: 98.64% (May vary between batches)
• Formula: C₁₈H₂₅NO₃S
• SMILES: CC(C)(C)c1cc(CC2SC(=O)NC2=O)cc(c1O)C(C)(C)C
• Target: Autophagy,Mitochondrial Metabolism
• Solubility: DMSO:250 mg/mL (745.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.9 mM)

Bioactivity

• In Vivo:
  NL-1 showed antileukemic activity in an in vivo mouse ALL model
• In Vitro:
  NL-1 Reduced the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner.
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• Cell Research:
  Cell Line:REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines. Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 100 μM.Incubation Time:72 hours
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• Animal Research:
  Animal Model:10 female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells. Dosage:10 mg/kg.Administration:Intraperitoneal injection; daily; for 5 days
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

acute, anti-cancer, antileukemic, Autophagy, B-Cell, CISD1, MitoNEET, mitoNEET, Mitochondrial Metabolism, MitochondrialMetabolism, NL 1, NL1, NL-1, inhibit, Inhibitor, lymphoblastic, leukemia, viability

Compound Identifiers

PubChem CID

9819104