Nizatidine

SKU: orb1308127

Description

Nizatidine is a reversible, competitive antagonist of the histamine H2 receptor that also exhibits antacid properties. It is widely used in research to investigate gastric acid secretion, both in vitro using cell-based assays and in vivo for ulcer models and pharmacokinetic studies.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76963-41-2
• MW: 331.46
• Purity: 99.87% (May vary between batches)
• Formula: C₁₂H₂₁N₅O₂S₂
• SMILES: CN\C(NCCSCc1csc(CN(C)C)n1)=C\[N+]([O-])=O
• Target: Histamine Receptor|||Cholinesterase (ChE)
• Solubility: H2O:26 mg/mL (78.44 mM);DMSO:60 mg/mL (181.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.96 mM);Ethanol:15 mg/mL (45.25 mM)

Bioactivity

• Target IC50:
  AChE:6.7 μM|H2 receptor:0.9 nM
• In Vivo:
  Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase (IC50=6.7 μM, Ki=7.4 μM) and a selective antagonist of the histamine H2 receptor, effectively inhibiting gastric acid secretion (IC50=0.9 nM).
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• In Vitro:
  In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μMol/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% of the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

stomach, Zanizal, Axid, cancer, Acinon, acid, AChE, inhibit, intestines ulcers, Nizatidine, H2 receptor, GERD, erosive esophagitis, Inhibitor, gastroesophageal reflux disease, hcc, Histamine Receptor, HistamineReceptor

Compound Identifiers

PubChem CID

5353831