Nizatidine

SKU: orb1308127

Description

Nizatidine

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76963-41-2
• MW: 331.46
• Purity: 99.87%
• Formula: C₁₂H₂₁N₅O₂S₂
• SMILES: CN\C(NCCSCc1csc(CN(C)C)n1)=C\[N+]([O-])=O
• Target: Cholinesterase (ChE),Histamine Receptor
• Solubility: H2O:26 mg/mL (78.44 mM);DMSO:60 mg/mL (181.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.96 mM);Ethanol:15 mg/mL (45.25 mM)

Bioactivity

• Target IC50:
  AChE:6.7 μM|H2 receptor:0.9 nM
• In Vivo:
  Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase IC50 6.7 μM, K = .4 μM) and a Selective antagonist o the histamine H2 receptor, effectively inhibiting gastric acid secretion IC50 0.9 nM).
• In Vitro:
  In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μM L/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% o the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

stomach, Zanizal, Axid, cancer, Acinon, acid, AChE, inhibit, intestines ulcers, Nizatidine, H2 receptor, GERD, erosive esophagitis, Inhibitor, gastroesophageal reflux disease, hcc, Histamine Receptor, HistamineReceptor

Compound Identifiers

PubChem CID

5353831