Nizatidine

SKU: orb1224036

Description

Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion.(In Vivo):Nizatidine (oral gavage; 27 mg/kg; once daily; at 12 weeks of age and were sacrificed at 30 weeks after development of HCC in the setting of nonalcoholic steatohepatitis (NASH)) results in a 35% reduction of tumor nodules relative to controls. Nizatidine results in a 60% reduction in tumor nodules, reduces collagen proportional area and expression of profibrotic markers in DEN-injured rats.Nizatidine (oral gavage; 27 mg/kg; once daily; 4 weeks) decreases the incidence of gastric ulceration, and significantly decreases the mean ulcer score and ulcer index in male albino rats.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76963-41-2
• MW: 331.46
• Purity: >98% (HPLC)
• Formula: C₁₂H₂₁N₅O₂S₂
• SMILES: CN/C(NCCSCC1=CSC(CN(C)C)=N1)=C\[N+]([O-])=O
• Target: AChR
• Solubility: Ethanol: 18 mg/mL (54.3 mM); Water: 28 mg/mL (84.47 mM); DMSO: 66 mg/mL (199.11 mM)

Bioactivity

• In Vivo:
  Nizatidine (oral gavage; 27 mg/kg; once daily; at 12 weeks of age and were sacrificed at 30 weeks after development of HCC in the setting of nonalcoholic steatohepatitis (NASH)) results in a 35% reduction of tumor nodules relative to controls. Nizatidine results in a 60% reduction in tumor nodules, reduces collagen proportional area and expression of profibrotic markers in DEN-injured rats. Nizatidine (oral gavage; 27 mg/kg; once daily; 4 weeks) decreases the incidence of gastric ulceration, and significantly decreases the mean ulcer score and ulcer index in male albino rats. Animal model: Male albino rats. Dosage: 27 mg/kg. Administration: Oral gavage; 27 mg/kg; once daily; 4 weeks. Result: Was effective in the management of NSAIDs induced peptic ulcer in rats.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY139037

Quick Database Links

Gene Symbol

AChR