Nitric oxide production-IN-11k

SKU: orb3028918

Description

Nitric oxide production-IN-11k is a compound that inhibits TLR4, JNK, and NF-κB signaling pathways. It suppresses nitric oxide (NO) production in LPS-stimulated RAW264.7 cells, with an IC₅₀ of 23.2 µM. By downregulating TLR4 expression and reducing the phosphorylation level of JNK, Nitric oxide production-IN-11k inhibits the activation of NF-κB, thereby blocking the transcription of inflammation-related genes. This leads to decreased expression of iNOS and COX-2, and consequently reduces the production of inflammatory mediators such as NO, PGE₂, and TNF-α, exerting anti-inflammatory effects. Nitric oxide production-IN-11k shows potential application value in the study of rheumatoid arthritis and other inflammatory diseases.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1019984-44-1
• MW: 344.403
• Formula: C₂₃H₂₀O₃
• SMILES: O=C1C2=CC=C(OC)C=C2C(C=3C=CC=CC3)C1C4=CC=C(OC)C=C4
• Target: JNK,NF-κB,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK,NF-κB,TLR