Nicergoline

SKU: orb1225445

Description

Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.(In Vitro):Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death.Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia.(In Vivo):Nicergoline (10 mg/kg; i.v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease.Nicergoline (10 mg/kg; i.v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice.

Key Properties

• CAS Number: 27848-84-6
• MW: 484.39
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₆BrN₃O₃
• SMILES: O=C(C1=CC(Br)=CN=C1)OC[C@H](C[C@]23OC)CN(C)[C@]3([H])CC4=CN(C)C5=C4C2=CC=C5
• Target: Adrenergic Receptor
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Nicergoline (10 mg/kg; i. v. once daily for 60 d) improves impaired neurogenesis and cognitive competence in mice with Alzheimer's disease. Nicergoline (10 mg/kg; i. v. once daily for 60 d) inhibits apoptosis, inflammation and oxidative stress in hippocampal cells, and regulates the activity of hippocampal cells through the PI3K/AKT signaling pathway in mice. Animal model: 3×Tg-AD mice (male, 28-35 g, 6 weeks) with the Alzheimer's disease. Dosage: 10 mg/kg. Administration: I. v. once daily for 60 days. Result: Improved neurogenesis and cognitive competence. Decreased the degree of dementia. Downregulated pathogenic Aβ-42 and-40 peptides and APP in the hippocampi. Increased Levels of the neuroprotective forkhead box protein P2 (Foxp2), Src homology 2-containing inositol phosphatase (SxIP) and end-binding proteins (EB) in the hippocampi. Exhibited marked differences in the dispersion of the pyramidal cell layer between the nicergoline-treated and control groups.
• In Vitro:
  Nicergoline (0.3-30 μM; 24 h) attenuates activated microglia- and astrocytes-induced neuronal cell death. Nicergoline (0.3-30 μM; 48 h) suppresses the production of proinflammatory cytokines and superoxide anion by activated microglia.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nicergoline, Nicotergoline, Nimergoline, Sermion

Quick Database Links

Gene Symbol

Adrenergic Receptor