NIBR189

SKU: orb1300020

Description

NIBR189 is a potent and selective EBI2 (GPR183) receptor antagonist, exhibiting IC50 values of 11 nM and 15 nM for human and mouse receptors, respectively. This tool compound is used in vitro and in vivo to investigate the role of EBI2 in immune cell migration and inflammatory diseases.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1599432-08-2
• MW: 429.31
• Purity: 97.00% (May vary between batches)
• Formula: C₂₁H₂₁BrN₂O₃
• SMILES: COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Br)cc1
• Target: EBI2/GPR183
• Solubility: DMSO:47 mg/mL (109.48 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.66 mM)

Bioactivity

• Target IC50:
  EBI2/GPR183 receptor (human):11 nM |EBI2 (GPR183) receptor (mouse):15 nM
• In Vitro:
  NIBR189 is selective for EBI2 over a panel of other receptors, enzymes, and transporters. NIBR189 blocks the oxysterol-induced migration of U937 monocytic cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

small molecule, U937, autoimmune, autoimmune diseases, EBI2, EBI2/GPR183, GPR183, G protein, mice, migration, NIBR 189, NIBR189, NIBR-189, inhibit, Inhibitor

Compound Identifiers

PubChem CID

36295259