Cart summary

You have no items in your shopping cart.

NIBR189

SKU: orb1220527

Description

NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors respectively).

Images & Validation

Key Properties

CAS Number1599432-08-2
MW429.31
Purity>98% (HPLC)
FormulaC21H21BrN2O3
SMILESCOc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)\C=C\c1ccc(Br)cc1
TargetGPR
SolubilityDMSO:47 mg/mL (109.48 mM)

Bioactivity

In Vitro
NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells. NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM. Cell Migration Assay Cell line: U937 cell lines. Concentration: 0-1 μM. Incubation time: 3 hours. Result: Blocked the direct migration of U937 cells with an IC50 value of 0.3 nM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • NIBR189 [orb1300020]

    97.00%

    1599432-08-2

    429.31

    C21H21BrN2O3

    10 mg, 100 mg, 1 mg, 5 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO)
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

NIBR189 (orb1220527)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 140.00
10 mg
$ 210.00
25 mg
$ 360.00
50 mg
$ 610.00
100 mg
$ 890.00