NGI-1

SKU: orb1299880

Description

NGI-1 (ML414) is a cell-permeable small molecule that selectively inhibits oligosaccharyltransferase (OST). This inhibition effectively reduces viral infectivity in vitro while maintaining cell viability, making it a valuable tool for researching N-linked glycosylation in virology and cell biology.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 790702-57-7
• MW: 394.51
• Purity: >98%
• Formula: C₁₇H₂₂N₄O₃S₂
• SMILES: CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)Nc1ncc(C)s1
• Target: Glycosylation
• Solubility: Soluble in DMSO (up to 5 mg/ml)

Bioactivity

• In Vitro:
  In non-small-cell lung cancer cells, NGI-1 blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or fibroblast growth factor, FGFR) for survival.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML414

Compound Identifiers

PubChem CID

2519269