NF-κB-IN-1

SKU: orb1298366

Description

NF-κB-IN-1 is a synthetic 4-arylidene curcumin analog that acts as a potent inhibitor of the NF-κB signaling pathway by directly targeting IKK. This compound has demonstrated efficacy in vitro by reducing the viability and clonogenic growth of lung cancer cells such as A549.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1227098-15-8
• MW: 530.57
• Purity: 99.03% (May vary between batches)
• Formula: C₃₁H₃₀O₈
• SMILES: COc1ccc(\C=C\C(=O)C(=Cc2ccc(O)c(OC)c2)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC
• Target: IκB/IKK,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.77 mM);DMSO:40 mg/mL (75.39 mM)

Bioactivity

• In Vitro:
  NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells.It(0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI50s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity. NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC50s of 1.0 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

crucumin, A549, 4-arylidene, 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-, cancer, I kappa B kinase, IκB kinase, IκB, inhibit, IkB, IkB/IKK, IKK, Inhibitor, NFκBIN1, NF-κB-IN-1, NF-κB, NFκB, NF-kB-IN-1, NFkB, NF-kB, NF κB IN 1, NF-kappaB-IN-1, pathway, signaling

Compound Identifiers

PubChem CID

49851904