Neurotensin(8-13)

SKU: orb1685464

Description

Neurotensin(8-13) is a bioactive fragment of the neurotensin peptide. This analog induces internalization and downregulation of neurotensin receptor 1 (NTR1). It is widely used in neuroscience and oncology research to study receptor trafficking and signaling in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60482-95-3
• MW: 816.99
• Purity: 99.95% (May vary between batches)
• Formula: C₃₈H₆₄N₁₂O₈
• SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O
• Target: Neurotensin Receptor
• Solubility: H2O:50 mg/mL (61.2 mM)

Bioactivity

• In Vivo:
  The internalization of the receptor induced by neurotensin (8-13) leads to a decrease in the density of the NT1 receptor (NTR1) on the cell surface.In ht-29 cells and rat primary cultured neurons, the neurotensin (NT) receptor was down-regulated by high concentrations of extracellular peptides.The representation of cell surface receptors is also different

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NTR1, Neurotensin Receptor, NeurotensinReceptor, Neurotensin(3TFA), Neurotensin(8 13), Neurotensin(813), Neurotensin(8-13)

Compound Identifiers

PubChem CID

5311318