Neurotensin(8-13) 3TFA(60482-95-3(free base))

SKU: orb1299655

Description

Neurotensin(8-13) 3TFA is the active C-terminal fragment of neurotensin. This peptide agonist is widely used in neuroscience and oncology research to study NTR1 receptor internalization and signaling in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2952825-79-3
• MW: 931.03
• Purity: 100.00%
• Formula: C₄₀H₆₅F₃N₁₂O₁₀
• SMILES: OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O
• Target: Neurotensin Receptor
• Solubility: DMSO:22.5 mg/mL (24.17 mM)

Bioactivity

• In Vivo:
  The internalization of the receptor induced by neurotensin (8-13) leads to a decrease in the density of the NT1 receptor (NTR1) on the cell surface.In ht-29 cells and rat primary cultured neurons, the neurotensin (NT) receptor was down-regulated by high concentrations of extracellular peptides.The representation of cell surface receptors is also different

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NTR1, Neurotensin 3TFA(60482-95-3(free base)), Neurotensin Receptor, Neurotensin(8 13) 3TFA(60482 95 3(free base)), Neurotensin(813) 3TFA(60482953(free base)), NeurotensinReceptor

Compound Identifiers

PubChem CID

137700236