Nepodin

SKU: orb1297555

Description

Nepodin is a bioactive small molecule with antimalarial, anti-inflammatory, and antidiabetic properties. Its anti-inflammatory action involves cyclooxygenase (COX) inhibition, while its antidiabetic effect is linked to AMPK activation and subsequent GLUT4 translocation, as demonstrated in cellular research.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 3785-24-8
• MW: 216.23
• Purity: 99.12% (May vary between batches)
• Formula: C₁₃H₁₂O₃
• SMILES: OC=1C2=C(C=C(C)C1C(C)=O)C=CC=C2O
• Target: transporter,AMPK,COX,Parasite
• Solubility: DMSO:50 mg/mL (231.24 mM)

Bioactivity

• In Vitro:
  To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified Nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of Nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, Nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, Nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLUT, Parasite, Nepodin, Musizin, Inhibitor, inhibit, COX, AMP-activated protein kinase, AMPK

Compound Identifiers

PubChem CID

100780