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NEDD4 (M) Antibody, Rabbit Polyclonal
Catalog Number: orb67227
| Catalog Number | orb67227 |
|---|---|
| Category | Antibodies |
| Description | Rabbit polyclonal to NEDD4.Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form ofa thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4 is also involved inthe pathway leading to the degradation of VEGFR-2/KDFR independent of its ubiquitin-ligase activity.NEDD4 can monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization anddegradation in lysosomes. In addition, NEDD4 is part of a signaling complex composed of NEDD4,RAP2A and TNIK, which regulates neuronal dendrite extension and arborization during development. |
| Clonality | Polyclonal |
| Species/Host | Rabbit |
| Conjugation | Unconjugated |
| Reactivity | Human, Mouse |
| Buffer/Preservatives | 0.01% NaN3 |
| Purity | Affinity purification |
| Immunogen | middle region of human NEDD4 |
| UniProt ID | P46934 |
| MW | 149 |
| Tested applications | WB |
| Dilution range | WB:1:1000-1:5000 |
| Storage | -20°C |
| Alternative names | anti-NEDD4 antibody,anti-E3 ubiquitinprotein ligas Read more... |
| Note | For research use only |
Western blot analysis of total cell extracts from human Hela(Lane1) and mouse brain(Lane2) using NEDD4 antibody
