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Necrosulfonamide
Catalog Number: orb1300359
| Catalog Number | orb1300359 |
|---|---|
| Category | Small Molecules |
| Description | Necrosulfonamide |
| Purity | 99.49% |
| MW | 461.47 |
| Biological Activity | (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis. |
| CAS Number | [1360614-48-7] |
| Formula | C18H15N5O6S2 |
| SMILES | COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)\C=C\c2ccc(s2)[N+]([O-])=O)cc1 |
| Storage | -20°C |
| Note | For research use only |
(E/Z)-Necrosulfonamide [orb1300044]
97.62%
432531-71-0
461.47
C18H15N5O6S2
2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
