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Necrosulfonamide
Catalog Number: orb1300359
| Catalog Number | orb1300359 |
|---|---|
| Category | Small Molecules |
| Description | Necrosulfonamide |
| CAS Number | 1360614-48-7 |
| Purity | 99.17% |
| MW | 461.47 |
| SMILES | S(NC=1C(OC)=NC=CN1)(=O)(=O)C2=CC=C(NC(/C=C/C=3SC(N(=O)=O)=CC3)=O)C=C2 |
| Formula | C18H15N5O6S2 |
| Biological Activity | (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Necrosulfonamide (NSA) [orb14391]
[1360614-48-7]
461.47
C18H15N5O6S2
1 g, 100 mg, 250 mg, 10 mM * 1 mL in DMSONecrosulfonamide [orb1226452]
> 98% (HPLC)
1360614-48-7
100 mg, 50 mg, 25 mg, 10 mg, 5 mg, 1 g, 500 mgNecrosulfonamide(b) [orb1220501]
> 98% (HPLC)
432531-71-0
50 mg, 25 mg, 100 mg, 10 mg, 5 mg, 1 g, 500 mg, 200 mg(E/Z)-Necrosulfonamide [orb1300044]
98%
432531-71-0
461.47
C18H15N5O6S2
5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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