(E/Z)-Necrosulfonamide

SKU: orb1300044

Description

Necrosulfonamide

Research Area

Signal Transduction

Key Properties

• CAS Number: 432531-71-0
• MW: 461.47
• Purity: 98.00%
• Formula: C₁₈H₁₅N₅O₆S₂
• SMILES: COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)C=Cc2ccc(s2)[N+]([O-])=O)cc1
• Target: MLK
• Solubility: DMSO:25 mg/mL (54.17 mM)

Bioactivity

• In Vivo:
  Necrosulfonamide attenuate the spinal cord injury via necroptosis inhibitio
• Animal Research:
  Pathologic condition was detected using hematoxylin-eosin staining on injured spinal cord and Other major organs. Necroptosis-related factors-RIP1, RIP3, and MLKL-were detected using Western blot. Detections on mitochondrial functions such as adenosine triphosphate generation and activities of superoxide dismutase and caspase-3 were also performed. Finally, ethologic performance was detected using a 21-point open-ffield locomotion tes.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

necrosis(MLKL), Necrosulfonamide

Compound Identifiers

PubChem CID

2915669