NDI-101150

SKU: orb3032914

Description

NDI-101150​ is a highly selective, orally bioavailable small-molecule inhibitor targeting hematopoietic progenitor kinase 1 (HPK1/MAP4K1), a key negative regulator of T-cell signaling. This compound demonstrates potent immunomodulatory activity by enhancing T-cell activation and proliferation, while simultaneously exhibiting robust antitumor efficacy in preclinical models. Its mechanism of action involves disrupting HPK1-mediated suppression of immune responses, leading to improved T-cell function and sustained inhibition of tumor progression. With its favorable pharmacokinetic profile and specificity for HPK1, NDI-101150 represents a promising therapeutic candidate for cancer immunotherapy, particularly in settings where T-cell activity is compromised.

Key Properties

• CAS Number: 2628486-22-4
• MW: 486.540688753128
• Purity: >98%
• Formula: C₂₇H₂₇FN₆O₂
• SMILES: C1(=O)C2=C(C(C3N4C(=NC=3)C=C(F)C=C4)=CC=C2NC2=NC(CN(C)C)=C([C@@H]3CCOC3)C=C2)CN1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only