ND-646

SKU: orb1296104

Description

ND-646

Research Area

Metabolism Research

Key Properties

• CAS Number: 1434639-57-2
• MW: 568.64
• Purity: 99.65%
• Formula: C₂₈H₃₂N₄O₇S
• SMILES: COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)-c1ncco1)OC1CCOCC1
• Target: Acetyl-CoA Carboxylase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.8 mM);DMSO:95 mg/mL (167.07 mM)

Bioactivity

• Target IC50:
  ACC1 (human):3.5 nM |ACC2 (human):4.1 nM
• In Vivo:
  ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, ND 646, ND646, ND-646, AcetylCoACarboxylase, AcetylCoA Carboxylase, Acetyl-CoA Carboxylase, ACC, Acetyl Coenzyme A Carboxylase, ACC

Compound Identifiers

PubChem CID

71570560