ND-646

SKU: orb1220035

Description

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2(IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively)ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC.

Key Properties

• CAS Number: 1434639-57-2
• MW: 568.64
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₂N₄O₇S
• SMILES: COc1ccccc1[C@H](Cn1c2sc(-c3ncco3)c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)OC1CCOCC1
• Target: ACC
• Solubility: DMSO:95 mg/mL (167.06 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ACC