NCB-0846

SKU: orb1690830

Description

NCB-0846 is a potent, cell-permeable small molecule inhibitor targeting TNIK with an IC50 of 21 nM. It is utilized in biochemical and cellular research to investigate Wnt signaling pathways and has shown efficacy in reducing tumor growth in preclinical colorectal cancer models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1792999-26-8
• MW: 375.42
• Purity: 99.89%
• Formula: C₂₁H₂₁N₅O₂
• SMILES: O[C@H]1CC[C@H](CC1)Oc1cccc2cnc(Nc3ccc4nc[nH]c4c3)nc12
• Target: MAPK,Wnt/beta-catenin,TGF-beta/Smad
• Solubility: DMSO:50 mg/mL (133.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.33 mM)

Bioactivity

• Target IC50:
  TNIK:21 nM
• In Vivo:
  Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

betacatenin, beta-catenin, bcatenin, inhibit, Inhibitor, NCB 0846, NCB0846, NCB-0846, MAPK Kinase Kinase Kinase, MAP4K, TNIK, Wnt/b-catenin, Wnt, Wnt/betacatenin, Wnt/β-catenin, βcatenin

Compound Identifiers

PubChem CID

91801204