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NCB-0846

SKU: orb1225904

Description

The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM; also weakly inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK (IC80>0.1 uM); induces faster migration of TCF4 phosphorylated by TNIK at 0.1-0.3 uM, and completely inhibits at 3 uM; also reduces the expression of TNIK, AXIN2, cMYC, LRP6 and LRP5; abrogates colorectal cancer stemness, suppresses Wnt-driven intestinal tumorigenesis in Apc(min/+) mice. Colon Cancer Preclinical.

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Key Properties

CAS Number1792999-26-8
MW375.4237
Purity>98% (HPLC)
FormulaC21H21N5O2
SMILESO[C@H]1CC[C@@H](OC2=CC=CC3=CN=C(NC4=CC=C5N=CNC5=C4)N=C23)CC1
TargetTNIK
SolubilityDMSO: ≥ 30 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NCB 0846 | NCB0846

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NCB-0846 (orb1225904)

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Available Sizes

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200 mg
500 mg
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 370.00
50 mg
$ 600.00
100 mg
$ 870.00