Natalizumab

• Catalog Number: orb1290234
• Category: Antibodies
• Description: Natalizumab biosimilar antibody
• Species/Host: Mouse
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human
• CAS Number: 189261-10-7
• Isotype: IgG4-kappa
• Antibody Type: Biosimilar Antibody
• Purity: > 95%
• Conjugation: Unconjugated
• Target: ITGA4/CD49d
• Source: CHO cells
• Biological Activity: Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: PBS buffer pH 7.5
• Alternative names: AN 100226, BG00002
• Note: For research use only
• Expiration Date: 12 months from date of receipt.