Naproxen sodium

SKU: orb1308091

Description

Naproxen sodium is a non-selective cyclooxygenase (COX) inhibitor with analgesic and antipyretic properties. It is widely used in research to study inflammation, pain, and fever mechanisms in both in vitro enzymatic assays and in vivo animal models.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 26159-34-2
• MW: 252.24
• Purity: >99.99% (May vary between batches)
• Formula: C₁₄H₁₃NaO₃
• SMILES: c12c(cc(cc2)OC)ccc(c1)[C@@H](C(=O)[O-])C.[Na+]
• Target: COX,Autophagy
• Solubility: H2O:198.2 mM;DMSO:4.55 mg/mL (18.04 mM)

Bioactivity

• Target IC50:
  COX-2:5.2 μM|COX-1:8.7 μM
• In Vivo:
  In HCA-7 colon cancer cells (IC50=1.45 mM), high concentrations of Naproxen induce apoptosis. Within cells, Naproxen inhibits COX-1 (IC50=2.2 μg/mL) and COX-2 (IC50=1.3 μg/mL).
• In Vitro:
  In rat models of carrageenan-induced arthritis and attenuation of pain perception (IC50=27 μM) as well as yeast-induced fever (IC50=40 μM), Naproxen exhibits inhibitory effects. Additionally, in rats, Naproxen suppresses the production of PGE2 (IC50=12.8 μM) and TXB2 (IC50=5.9 μM) triggered by lipopolysaccharides.
• Cell Research:
  Cells are exposed to Naproxen for 24 and 48 hours, respectively. At the end of incubation, cells are harvested by trypsinization, stained with trypan blue solution (0.04% wt/vol) and counted in a Neubauer haemocytometer chamber for the determination of cell viability.(Only for Reference)

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RS 3650, RS3650, RS-3650, inhibit, Miranax, Naproxen sodium, Naprelan, Naproxen, Inhibitor, Anaprox, Autophagy, COX-1, COX-2, COX, Cyclooxygenase

Compound Identifiers

PubChem CID

23681059