Naproxen sodium

SKU: orb1225480

Description

Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.(In Vitro):Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.(In Vivo):Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM).

Key Properties

• CAS Number: 26159-34-2
• MW: 252.24
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₃NaO₃
• SMILES: O=C([O-])[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1.[Na+]
• Target: COX
• Solubility: Water: 50 mg/mL (198.22 mM); DMSO: 3 mg/mL (11.89 mM)

Bioactivity

• In Vivo:
  Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50 = 27, 40, 13 μM).
• In Vitro:
  Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Naproxen sodium | RS 3650 | Sodium naproxen | Naproxen natrium

Quick Database Links

Gene Symbol

COX