Naphazoline

SKU: orb1940443

Description

Naphazoline is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 835-31-4
• MW: 210.28
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄N₂
• SMILES: C(C1=NCCN1)c1cccc2ccccc12
• Target: Adrenergic Receptor

Bioactivity

• In Vivo:
  Naphazoline (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF. Animal model: Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n = 8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin)). Dosage: 0.2 mg/mL, 10 μl per eye. Administration: Intraperitoneal injection (IP), once. Result: Significantly suppressed conjunctival dye leakage in mice with histamine or antigen induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Naphazoline | Naphcon-a | AK-Con | All Clear | Clear Eyes

Quick Database Links

Gene Symbol

Adrenergic Receptor