Naphazoline hydrochloride

SKU: orb1224696

Description

Naphazoline hydrochloride is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.(In Vivo):Naphazoline hydrochloride (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF.

Key Properties

• CAS Number: 550-99-2
• MW: 246.74
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₅ClN₂
• SMILES: [H]Cl.C1(CC2=C3C=CC=CC3=CC=C2)=NCCN1
• Target: Adrenergic Receptor
• Solubility: Ethanol: 22 mg/mL (89.16 mM); Water: 49 mg/mL (198.58 mM); DMSO: 17 mg/mL (68.89 mM)

Bioactivity

• In Vivo:
  Naphazoline hydrochloride (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF. Animal model: Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n = 8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin)). Dosage: 0.2 mg/mL, 10 μl per eye. Administration: Intraperitoneal injection (IP), once. Result: Significantly suppressed conjunctival dye leakage in mice with histamine or antigen induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-(1-Naphthylmethyl)-2-imidazoline

Quick Database Links

Gene Symbol

Adrenergic Receptor