Nampt-IN-5

SKU: orb1309358

Description

Nampt-IN-5 is a potent, orally bioavailable inhibitor of the enzyme NAMPT. It is a valuable research tool for studying nicotinamide metabolism in fields such as cancer research and aging, with utility in both cellular and animal model studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2380013-17-0
• MW: 427.5
• Purity: 99.30% (May vary between batches)
• Formula: C₂₅H₂₅N₅O₂
• SMILES: CCOc1nc2ccccc2n1Cc1ccc(NC(=O)N2CC(C2)c2cccnc2)cc1
• Target: NAMPT,Cytochromes P450
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.68 mM);DMSO:48 mg/mL (112.28 mM)

Bioactivity

• Target IC50:
  CYP3:0.7 nM
• In Vitro:
  Nampt-IN-5 shows a good ADME data: mouse microsomal clearance, CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.Nampt-IN-5 has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively in CellTiterGlo (CTG) assays.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pre-B cell colony enhancing factor, Visfatin, inhibit, Inhibitor, NAMPT, Nampt, Nampt IN 5, NamptIN5, Nampt-IN-5, Nicotinamide phosphoribosyl transferase, PBEF, Cytochrome P450, CYPs, COR-L23, A2780

Compound Identifiers

PubChem CID

146014464