Nampt-IN-5

SKU: orb1218323

Description

Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .

Key Properties

• CAS Number: 2380013-17-0
• MW: 427.5
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₅N₅O₂
• SMILES: O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3
• Target: NAMPT
• Solubility: DMSO:48mg/ml(112.28mM;Need ultrasonic)

Bioactivity

• In Vivo:
  Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle. Nampt-IN-5 (10 mg/kg; p.o.) exhibits T1/2 (2.1 h), Cmax (29112 nM), and AUC (61984 nM h) in mice.
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• In Vitro:
  Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min mg), CYP3A4 inhibition value (0.75 μM), Sol6.8: 0.056 mM; MDCK Papp AB: 18.6.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NAMPT