Naftopidil hydrochloride

SKU: orb1298269

Description

Naftopidil hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1164469-60-6
• MW: 428.95
• Purity: 99.95%
• Formula: C₂₄H₂₉ClN₂O₃
• SMILES: Cl.COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
• Target: Adrenergic Receptor
• Solubility: DMSO:60 mg/mL (139.88 mM)

Bioactivity

• Target IC50:
  α1B-adrenoceptor:20 nM|α1D-adrenoceptor:1.2 nM|α1A-adrenoceptor (human):3.7 nM
• In Vivo:
  Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells.
• In Vitro:
  Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α1-adrenoceptor, pressure, prostatic, prostate, Naftopidil, Naftopidil hydrochloride, Naftopidil Hydrochloride, KT 611, KT 611 Hydrochloride, KT611, KT-611, KT611 Hydrochloride, KT-611 Hydrochloride, KT-611 hydrochloride, inhibit, Inhibitor, hyperplasia, BM15275, BM-15275, BM15275 Hydrochloride, BM-15275 Hydrochloride, BM-15275 hydrochloride, BM 15275, BM 15275 Hydrochloride, canine, Adrenergic Receptor, AdrenergicReceptor, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-, Beta Receptor

Compound Identifiers

PubChem CID

6603044