Naftopidil hydrochloride

SKU: orb1219072

Description

Naftopidil hydrochloride is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1164469-60-6
• MW: 428.95
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₉ClN₂O₃
• SMILES: OC(COC1=C2C=CC=CC2=CC=C1)CN3CCN(C4=CC=CC=C4OC)CC3.[H]Cl
• Target: Adenosine Receptor

Bioactivity

• In Vivo:
  Naftopidil hydrochloride (10 mg/kg; p. o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model. Animal model: Male athymic mice(7-8 weeks), with E9+PrSC xenograft. Dosage: 10 mg/kg. Administration: Oral administration, daily, for 28 days. Result: Decreased tumor weights.
• In Vitro:
  Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC. Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC. Cell Proliferation Assay Cell line: PCa cells, PrSC. Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) Incubation time: 3 days. Result: Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners. Western blot analysis. Cell line: PCa cells, PrSC. Concentration: 50 μM (E9 cells), 25 μM (PrSC). Incubation time: 48 hours. Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KT-611 hydrochloride | BM-15275 hydrochloride | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-

Quick Database Links

Gene Symbol

Adenosine Receptor