Mutant IDH1 inhibitor

SKU: orb1308000

Description

This small molecule inhibitor potently targets the mutant IDH1 R132H enzyme with an IC50 under 72 nM. It is a valuable research tool for investigating oncogenic mechanisms in models of glioma and AML, supporting both in vitro and in vivo studies.

Research Area

Metabolism Research, Metabolism Research; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1429180-08-4
• MW: 466.58
• Purity: 97.72% (May vary between batches)
• Formula: C₂₅H₃₄N₆O₃
• SMILES: CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(CC3)C(C)=O)cc2)n1
• Target: Dehydrogenase,Isocitrate Dehydrogenase (IDH)
• Solubility: DMSO:30 mg/mL (64.3 mM)

Bioactivity

• Target IC50:
  IDH1 (mutant, R132H):< 72 nM
• In Vitro:
  Mutant IDH1 inhibitor is used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IsocitrateDehydrogenase, IsocitrateDehydrogenase(IDH), Isocitrate Dehydrogenase (IDH), Mutant IDH1 inhibitor, Mutant IDH-1 inhibitor, mutant IDH1 R132H, Isocitrate Dehydrogenase, inhibit, IDH, Inhibitor

Compound Identifiers

PubChem CID

71542482