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Mutant IDH1 inhibitor

SKU: orb1308000

Description

This small molecule inhibitor potently targets the mutant IDH1 R132H enzyme with an IC50 under 72 nM. It is a valuable research tool for investigating oncogenic mechanisms in models of glioma and AML, supporting both in vitro and in vivo studies.

Research Area

Metabolism Research, Metabolism Research; Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1429180-08-4
MW466.58
Purity98.30% (May vary between batches)
FormulaC25H34N6O3
SMILESCC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(CC3)C(C)=O)cc2)n1
TargetIsocitrate Dehydrogenase (IDH),Dehydrogenase
SolubilityDMSO:30 mg/mL (64.3 mM)

Bioactivity

Target IC50
IDH1 (mutant, R132H):< 72 nM
In Vitro
Mutant IDH1 inhibitor is used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IsocitrateDehydrogenase, IsocitrateDehydrogenase(IDH), Isocitrate Dehydrogenase (IDH), Mutant IDH1 inhibitor, Mutant IDH-1 inhibitor, mutant IDH1 R132H, Isocitrate Dehydrogenase, inhibit, IDH, Inhibitor

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 180.00
25 mg
$ 280.00
50 mg
$ 390.00
100 mg
$ 520.00
200 mg
$ 710.00
DispatchUsually dispatched within 5-10 working days
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