Vorasidenib

SKU: orb1299935

Description

Vorasidenib is a potent and selective small molecule inhibitor of mutant IDH1 and IDH2 enzymes, with IC50 values of approximately 32 nM. It is a valuable research tool for investigating oncogenic metabolism in cancers like glioma and cholangiocarcinoma, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1644545-52-7
• MW: 414.74
• Purity: 99.57% (May vary between batches)
• Formula: C₁₄H₁₃ClF₆N₆
• SMILES: C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F
• Target: Isocitrate Dehydrogenase (IDH)
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (7.96 mM);DMSO:63.75 mg/mL (153.71 mM)

Bioactivity

• Target IC50:
  IDH1 (R132H):31.9 nM |IDH2 (R140Q):31.7 nM
• In Vivo:
  Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, IDH, inhibit, IsocitrateDehydrogenase(IDH), mutant isocitrate dehydrogenase(mIDH), Isocitrate Dehydrogenase, Isocitrate Dehydrogenase (IDH), IsocitrateDehydrogenase, AG881, AG-881, AG 881, Vorasidenib, PVM/MA

Compound Identifiers

PubChem CID

117817422