Musk ketone

SKU: orb1301615

Description

Musk ketone

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 81-14-1
• MW: 294.30
• Purity: 98.00% (May vary between batches)
• Formula: C₁₄H₁₈N₂O₅
• SMILES: CC(=O)c1c(C)c(c(c(c1C)[N+]([O-])=O)C(C)(C)C)[N+]([O-])=O
• Target: Cytochromes P450,Others,PI3K,Akt,Apoptosis
• Solubility: DMSO:25 mg/mL (84.95 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.8 mM)

Bioactivity

• In Vivo:
  Musk ketone can reduce secondary damage after spinal cord injury and promote nerve recovery in rats.
• In Vitro:
  Similar to native musk, synthetic musk ketone induced the growth repression and the apoptosis of cancer cells. Additionally, numerous genes were differentially expressed in lung cancer cells after native musk treatment. These differentially expressed genes were involved in many signalling pathways. Among these pathways, apoptosis-related pathways included interleukin family, tumor necrosis factor family, and MAPK signalling pathway. Native musk and synthetic musk ketone can up-regulate IL-24 (interleukin family) and DDIT3 (MAPK signalling pathway) in lung cancer cells.
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• Cell Research:
  Twenty two cancer cell lines were treated with musk. Cell proliferation and apoptosis analyses were carried out. Native musk and synthetic musk ketone were analyzed by gas chromatograph-mass spectrometer (GC-MS) assay. Differentially expressed genes were determined by microarray and quantitative real-time polymerase chain reaction.
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• Animal Research:
  The rats weighed from 200 to 250 g and were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups). The Swash plate test and BBB behavioral score were used to determine neurological function recovery after spinal cord injury. Hematoxylin-eosin (HE) staining was used to detect general structural changes in spinal cord tissue. The enzyme-linked immunosorbent assay was used for the determination of interleukin 10 (IL-10) in spinal cord tissue. Compared with the NS control group, critical angle, BBB score and IL-10 levels in rat spinal cord tissue significantly increased in the MP group and MO groups 7 and 14 days after the operation. HE staining showed that in the NS group, there was hemorrhage, edema, necrosis, axonal demyelination, inflammatory cell infiltration and glial cell response in spinal cord tissue. After 7 days, spinal cord edema and inflammation were reduced and neuronal degeneration and necrosis were not evident in the MP and MO groups.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hep G2, Inhibitor, inhibit, Musk ketone, neuroprotective, Akt, Apoptosis, cerebral ischemia, PKB, PI3K, PI3K/Akt, Phosphoinositide 3-kinase, Protein kinase B

Compound Identifiers

PubChem CID

6669