Muramyl dipeptide

SKU: orb1217907

Description

Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 .

Key Properties

• CAS Number: 53678-77-6
• MW: 492.48
• Purity: >98% (HPLC)
• Formula: C₁₉H₃₂N₄O₁₁
• SMILES: CC(N[C@@H]1[C@@H](OC(C(N[C@H](C(N[C@H](CCC(O)=O)C(N)=O)=O)C)=O)C)[C@H](O)[C@@H](CO)O[C@@H]1O)=O
• Target: ERK
• Solubility: DMSO:98 mg/mL (198.99 mM);Water:98 mg/mL (198.99 mM)

Bioactivity

• In Vivo:
  Animal model: RANKL-induced osteoporosis model (Five-week-old C57BL/6 mice). Dosage: 1.25 mg/kg. Administration: i.p.; twice (RANKL-induced osteoporosis for 3 weeks and euthanized at 4 weeks). Result: Significantly enhanced the trabecular bone volume (BV/TV) and trabecular number (Tb. N).
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• In Vitro:
  Western blot analysis. Cell line: MC3T3-E1 cells. Concentration: 0.1, 1, 10 μg/mL Incubation time: 24 hours. Result: Increased protein expression of Runx2 in a dose-dependent manner. RT-PCR Cell line: MC3T3-E1 cells. Concentration: 0.1, 1, 10 μg/mL Incubation time: 6 hours. Result: Increases mRNA levels of Runx2 in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MDP

Quick Database Links

Gene Symbol

ERK