Muramyl dipeptide

SKU: orb1706939

Description

Muramyl dipeptide (MDP) is a synthetic immunoadjuvant peptide that promotes bone formation. It directly enhances osteoblast differentiation via Runx2 upregulation through MAPK signaling, while indirectly suppressing osteoclastogenesis by modulating the RANKL/OPG ratio. This makes it a valuable tool for studying bone metabolism and immunology in both cellular and animal models.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 53678-77-6
• MW: 492.48
• Purity: >99.99% (May vary between batches)
• Formula: C₁₉H₃₂N₄O₁₁
• SMILES: C[C@H](NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(=O)N[C@H](CCC(O)=O)C(N)=O
• Target: p38 MAPK,NOD,NOD-like Receptor (NLR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.15 mM);DMSO:50 mg/mL (101.53 mM);H2O:20 mg/mL (40.61 mM)

Bioactivity

• In Vivo:
  Muramyl dipeptide can be used for animal modeling to establish sepsis models. Muramyl dipeptide (1.25 mg/kg; intraperitoneal injection; twice) alleviates osteoporosis-induced bone loss.
• In Vitro:
  Muramyl dipeptide increases the protein expression of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 24 hours). It also enhances the mRNA levels of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 6 hours). Muramyl dipeptide indirectly attenuates osteoclast differentiation by reducing the RANKL/OPG ratio.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MDP, Muramyl dipeptide, NOD2, NLRP1

Compound Identifiers

PubChem CID

11620162